Gynazole-1: Basics, Side Effects & Reviews (2023)

Gynazole-1 (butoconazole nitrate vaginal cream) treats vaginal yeast infections with one dose, but it is expensive compared to other options.

COMMON BRANDS

Gynazole-1

DRUG CLASS

Antifungal

CONTROLLED SUBSTANCE CLASSIFICATION

Not a controlled medication

GENERIC STATUS

No lower-cost generic available

AVAILABILITY

Prescription only

Reviewed by:

Christina Aungst, PharmD

Michelle Nguyen, PharmD

Last reviewed on:

October 2, 2020

What is Gynazole-1?

How Gynazole-1 works

Gynazole-1 is an antifungal. It kills the fungus causing a yeast infection by damaging its protective outer layer.

What is Gynazole-1 used for?

  • Vaginal yeast infection

Gynazole-1 dosage forms

Gynazole-1: Basics, Side Effects & Reviews (1)

applicator

5.8g of 2%

Typical dosing for Gynazole-1

The dose for Gynazole-1 is to insert one applicatorful of cream into the vagina 1 time only. This medication can be used at any time of day.

Frequently asked questions about Gynazole-1

Gynazole-1: Basics, Side Effects & Reviews (2)

How long does it take Gynazole-1 to work?

Most people will feel relief within the first 24 hours after using Gynazole-1. Gynazole-1 is designed to stay in place in your vagina for 4 days after using. If you don't feel relief within 4 days, please contact your healthcare provider. You may need a different medication to treat your infection.

(Video) Uterine Prolapse and Incontinence Treatment: Pessary Insertion

Gynazole-1 hasn't been studied very much in pregnant women, so experts don't know if it is safe for pregnant women to use it. To be on the safe side, you shouldn't use Gynazole-1 if you are pregnant.

Both Monistat and Gynazole-1 work equally well to treat yeast infections. The choice for most people comes down to personal preference and cost. Gynazole-1 is very easy to use and works within 24 hours for most people, but it is very expensive and requires a prescription. Monistat is available over-the-counter and is much cheaper than Gynazole-1, but can take up to 3 days to kick in.

Yes, it is ok to use Gynazole-1 if you have your period. Just be sure to use pads or panty liners instead of tampons, as tampons can affect how well Gynazole-1 works. Avoid using tampons for 72 hours after using Gynazole-1.

Yes, there are a few single dose options that are cheaper than Gynazole-1. Fluconazole, a prescription option, is the cheapest product. You take a single pill and you should feel relief within 1 to 3 days. Monistat, an over-the-counter option, is also much cheaper than Gynazole-1. There is a 1 day version of Monistat available that provides relief within 3 to 7 days, although many people feel improvement within 24 hours. Always check with your healthcare provider first to see if it's ok for you to switch to an alternative medication.

Pros and cons of Gynazole-1

Pros

Gynazole-1: Basics, Side Effects & Reviews (7)Works well with a single dose

Gynazole-1: Basics, Side Effects & Reviews (8)Very easy to use and can be used any time of the day

Gynazole-1: Basics, Side Effects & Reviews (9)Very few drug interactions

Gynazole-1: Basics, Side Effects & Reviews (10)Leaks less than other vaginal alternatives

Cons

Gynazole-1: Basics, Side Effects & Reviews (11)Brand name only, so can be very expensive without insurance

Gynazole-1: Basics, Side Effects & Reviews (12)Can't use condoms or vaginal diaphragms for 72 hours after using Gynazole-1

Gynazole-1: Basics, Side Effects & Reviews (13)Shouldn't be used during pregnancy

Gynazole-1: Basics, Side Effects & Reviews (14)More side effects than other vaginal alternatives

Pharmacist tips for Gynazole-1

Gynazole-1: Basics, Side Effects & Reviews (15)Using Gynazole-1 is similar to using a tampon. Unwrap the applicator from its foil pouch. Don't remove the tip of the applicator. Pull the ring back fully to prepare the plunger to be used (similar to how you would pull the plunger back on a tampon before using). Gently insert the applicator into the vagina as far as it will comfortably go and push the plunger to release the medication. You can insert Gynazole-1 while sitting, standing with one leg raised, or lying down.

Gynazole-1: Basics, Side Effects & Reviews (16)Gynazole-1 break down condoms and diaphragms, so they will not work to prevent pregnancy or sexually transmitted infections. Do not have sex while using Gynazole-1, as this will make your symptoms worse.

Gynazole-1: Basics, Side Effects & Reviews (17)Gynazole-1 can be used at any time of day. It shouldn't leak out after you use it, so you can continue about your normal routine. You may want to wear a panty liner just in case, as Gynazole-1 can stain clothes.

Gynazole-1: Basics, Side Effects & Reviews (18)Gynazole-1 is designed to stay in the vagina and release medication slowly over 4 days. You should feel relief within that time. If you are still having symptoms over 4 days, contact your healthcare provider. You may need a different medication to treat your infection.

Gynazole-1: Basics, Side Effects & Reviews (19)Don't use tampons, douches, or spermicides while you're using Gynazole-1. They can affect how well Gynazole-1 works. It is okay to use it when you have your period, just be sure to use pads or other sanitary napkins.

Gynazole-1: Basics, Side Effects & Reviews (20)If you have frequent yeast infections (1 infection a month or more), talk to your healthcare provider. While Gynazole-1 should still be effective, there might be a reason why you're getting infections so often. Your provider can help figure out the cause and decrease the number of infections you get.

Gynazole-1: Basics, Side Effects & Reviews (21)

Prices for Gynazole-1 start at just $99.99 with a GoodRx coupon. They’re fast, easy-to-use and free!

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(Video) How to insert a suppository into the applicator from Women's International Pharmacy

What are the side effects of Gynazole-1?

With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.

Gynazole-1: Basics, Side Effects & Reviews (22) The following side effects may get better over time as your body gets used to the medication. Let your doctor know immediately if you continue to experience these symptoms or if they worsen over time.

Common side effects

  • Burning (6%)
  • Itching (6%)
  • Soreness and swelling (6%)
  • Pelvic and stomach pain (6%)
  • Cramping (6%)

Source: DailyMed

The following side effects have also been reported:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common

Vaginal burning, itching, discharge, or other irritation not present before use of this medicine

Rare

Skin rash or hives

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

Abdominal or stomach cramps or pain

burning or irritation of penis of sexual partner

headache

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

What are the risks and warnings for Gynazole-1?

Gynazole-1 can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options

ALLERGIC REACTIONS

Severe allergic reactions to Gynazole-1 while extremely rare are possible, including life-threatening problems like anaphylaxis (closing of the throat). Call 911 if this happens. If you notice hives, a rash, swelling of the lips or tongue, or difficulty breathing after taking Gynazole-1, call your healthcare provider right away.

(Video) How To Use Vaginal Cream

DAMAGE TO CONDOMS AND DIAPHRAGMS

Gynazole-1 can cause condoms and diaphragms to weaken and break. This puts you at risk for an unwanted pregnancy as well as sexually transmitted infections (STI). This effect continues for up to 72 hours after you use Gynazole-1. It's important to avoid having sex until your infection is cleared up, as sex can make your symptoms worse and it is possible to give your infection to your partner.

PREGNANCY WARNING

Gynazole-1 hasn't been studied very much in pregnant women, so experts don't know if it is safe for pregnant women to use it. To be on the safe side, you shouldn't use Gynazole-1 if you are pregnant. There are safer options available to treat vaginal yeast infections during pregnancy.

Interactions between Gynazole-1 and other medications

Gynazole-1 may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Gynazole-1. Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Tacrolimus
  • Warfarin

How much does Gynazole-1 cost?

There is currently no generic for Gynazole-1, so it can be expensive, even with insurance. GoodRx coupons, copay cards and patient assistance programs may help lower the cost.

Lowest GoodRx Price
Gynazole-1 (brand)

$99.99

Pricing based on most commonly-filled versions: 1 applicators (5.8g) of Gynazole-1 2%

What are alternatives to Gynazole-1?

There are a number of medications that your doctor can prescribe in place of Gynazole-1. Compare a few possible alternatives below.

Gynazole-1

Drug Class:Antifungal

Used for:

  • Vaginal yeast infection

$99.99

lowest GoodRx price

View Prices

Fluconazole (Diflucan)

Drug Class:Antifungal

Used for:

  • Vaginal yeast infection caused by Candida (oral tablets only)
  • Oral thrush of the mouth and throat caused by Candida
  • Meningitis caused by Cryptococcus
  • Bloodstream or systemic infection caused by Candida
  • Urinary tract infection caused by Candida
  • Peritonitis caused by Candida
  • Prevention of fungal infection for people have a bone marrow transplant

$6.00

lowest GoodRx price

View Prices

(Video) USE GARLIC THIS WAY TO GET RID OF YEAST IN 3 DAYS | Khichi Beauty

What is the latest news about Gynazole-1?

How to Get Rid of a Yeast Infection

The best way to get rid of a yeast infection is over the counter medications, and sometimes prescription medication. Some yeast infections may go away on their own but medications like Diflucan can help fight the infection and treat symptoms fast. Learn more about how to get rid of a yeast infection here.

Yeast Infection Pills: Is Diflucan a Good Yeast Infection Medication?

Yeast infection pills are a common, safe, and effective way to treat a yeast infection. See if a yeast infection pill is right for you here.

Yeast Infection Medicine: Is OTC Monistat (Miconazole) or Prescription Diflucan (Fluconazole) Better for Yeast Infections?

Yeast infection medicines such as Monistat and Diflucan are two of the most popular prescription and over-the-counter (OTC) treatments for yeast infections. Yeast infections are caused by an overgrowth of Candida albicans, a fungus naturally found in vaginal flora. Symptoms include itching, soreness, and white discharge with little odor. Here’s how to decide which yeast infection medicine to use.

Can You Use Boric Acid to Treat a Yeast Infection?

Boric acid can be used to treat yeast infections caused by Candida glabrata (a common yeast species). In fact, boric acid is frequently an ingredient in prescription and OTC medications for yeast infections. Learn more about boric acid and how it can be used to treat yeast infections with GoodRx.

Gynazole-1: Basics, Side Effects & Reviews (32)

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FAQs

How long does Gynazole-1 take to work? ›

How long does it take Gynazole-1 to work? Most people will feel relief within the first 24 hours after using Gynazole-1. Gynazole-1 is designed to stay in place in your vagina for 4 days after using. If you don't feel relief within 4 days, please contact your healthcare provider.

What happens after inserting Gynozol? ›

Increased vaginal/urethral burning/itching/pain, or mild abdominal cramps may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.

What are the side effects of yeast infection cream? ›

SIDE EFFECTS: Burning, stinging, swelling, irritation, redness, pimple-like bumps, tenderness, or flaking of the treated skin may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

How long does it take for yeast cream to work? ›

Most over-the-counter yeast infection treatments work within one to three days, depending on the brand. Your nurse or doctor can also prescribe you a single pill that you swallow (called Diflucan or fluconazole) to treat your yeast infection.

Is gynazole safe? ›

Note: GYNAZOLE•1® Butoconazole Nitrate Vaginal Cream USP, 2% is safe and effective in non-pregnant women; however, the safety and effectiveness of this product in pregnant women has not been established (see PRECAUTIONS - Pregnancy).

What are the side effects of Gynozol? ›

Gynazole may cause serious side effects including: hives, difficulty breathing, and. swelling of your face, lips, tongue, or throat.
...
Common side effects of Gynazole 1 include increased:
  • vaginal/urethral burning/itching/pain.
  • mild abdominal cramps.
  • pelvic pain.
  • soreness and swelling, or.
  • increased urination.

How much does gynazole cost? ›

Gynazole-1 (butoconazole topical) is a member of the vaginal anti-infectives drug class and is commonly used for Vaginal Yeast Infection.
...
Vaginal Cream.
QuantityPer unitPrice
5 grams$23.99$119.94

How long does it take a yeast infection suppository to dissolve? ›

However, it is important to make sure the suppository has completely dissolved before doing so to avoid mild skin irritation. It can take anywhere from 4-12 hours to dissolve, but each woman is individual, and times may be longer or shorter.

How long does it take for a suppository to dissolve? ›

Carefully push the suppository, tapered end first, about 1 inch into your bottom. Close your legs and sit or lie still for about 15 minutes to let it dissolve.

What happens after yeast infection treatment? ›

— Most yeast infections go away within a few days of starting treatment. However, you may continue to feel itchy and irritated, even after the infection is gone. If you do not get better within a few days after finishing treatment, call your doctor or nurse for advice.

What is the main cause of yeast infection? ›

The main cause of a yeast infection is the overgrowth of yeast on an area of the body. The yeast species Candida albicans causes common yeast infections, but other species of Candida can also cause an infection. They may need different treatment.

What causes vaginal itching? ›

Chlamydia, genital herpes, genital warts, trichomoniasis, gonorrhea and other organisms can cause vaginal/vulvar itching and irritation and other symptoms. Yeast infection (vaginal candidiasis). About three out of every four women will develop a yeast infection at some point in their lives.

How do you stop chronic yeast infections? ›

Taking an antifungal medication for three to seven days will usually clear a yeast infection. Antifungal medications — which are available as creams, ointments, tablets and suppositories — include miconazole (Monistat 3) and terconazole.

What cures yeast infection fast? ›

What is the fastest way to get rid of a yeast infection? The fastest — and most reliable — way to get rid of a yeast infection is to visit a doctor if you suspect you have one. They will likely prescribe fluconazole, an oral treatment that may take 1 week to get rid of the infection.

Which cream is best for fungal infection in private area? ›

Vaginal yeast infections are treated with antifungal drugs (antimycotics). The symptoms usually go away after a short course of treatment with these medications when used locally in the vagina.
...
The following medications are often used to treat vaginal yeast infections:
  • Clotrimazole.
  • Nystatin.
  • Ciclopirox.
  • Fluconazole.
19 Jun 2019

What is Gynomix used for? ›

Indication : Gynomix is indicated for the treatment of Vaginal mixed infections, Vaginal leucorrhoeas, Vaginal trichomoniasis if whatever their origin (Mycotic or Bacterial). Dosage and administration : Use in Vagina 1 capsule at night for 6 days. Or, as directed by the physician.

What happens when you insert clotrimazole? ›

Clotrimazole kills fungus by causing holes to appear in its cell membrane and the contents leak out. This kills the fungus and treats the infection. External symptoms such as itching and discharge should get better within 3 days.

How long does boric acid stay in your system? ›

The majority of boric acid in the body is eliminated in the urine within four days.

Can suppositories be used during periods? ›

People can take vaginal suppositories during a menstrual period. But they should use sanitary pads instead of tampons as tampons may absorb some of the medication. A person should take the medication for as long as directed, even if the symptoms go away.

Can I use clotrimazole during my period? ›

Use this medicine for the full prescribed length of time, even during your menstrual period. Your symptoms may improve before the infection is completely cleared. If the infection does not clear up, or if it appears to get worse, see your doctor.

How do I insert clotrimazole tablet without applicator? ›

If you are inserting the tablet without an applicator, lie on your back with knees towards your chest, and place the suppository on the tip of your finger. Gently insert the suppository high into the vagina as far as it will comfortably go.

What is the fastest way to get rid of a yeast infection? ›

The fastest — and most reliable — way to get rid of a yeast infection is to visit a doctor if you suspect you have one. They will likely prescribe fluconazole, an oral treatment that may take 1 week to get rid of the infection.

Will my period flush out yeast infection? ›

Indeed, she adds, estrogen levels are low during menstruation, and blood might actually help flush out some of that yeast, providing relief.

Why does my yeast infection keeps coming back? ›

A lack of regular hygiene practices, such as daily showers and brushing your teeth, or a constantly damp environment can also lead to chronic yeast infections. You're also at risk of recurring yeast infections if you have a weakened immune system. The following can weaken your immune system: age.

Can a woman give a man a yeast infection? ›

Yeast infections are not STIs. But it is possible to pass yeast infections to your partner during vaginal, oral, or anal sex. If your partner is a man, the risk of infection is low. About 15% of men get an itchy rash on the penis if they have unprotected sex with a woman who has a yeast infection.

What foods cause yeast infections? ›

Foods containing simple sugars, including many fruits. White flour and other glutenous grains. Anything fermented with yeast, such as alcoholic drinks. Some dairy products, including whole milk.

Why is my Vigina itchy inside? ›

Chlamydia, genital herpes, genital warts, trichomoniasis, gonorrhea and other organisms can cause vaginal/vulvar itching and irritation and other symptoms. Yeast infection (vaginal candidiasis). About three out of every four women will develop a yeast infection at some point in their lives.

What do I do if my yeast infection won't go away? ›

So if your yeast infection isn't going away on its own or with over-the-counter treatment, see a gynecologist or other healthcare provider. You might need further testing and a secondary course of prescription antifungal medication.

What is the main cause of yeast infection? ›

The main cause of a yeast infection is the overgrowth of yeast on an area of the body. The yeast species Candida albicans causes common yeast infections, but other species of Candida can also cause an infection. They may need different treatment.

What causes yeast infection in female? ›

The fungus candida albicans is responsible for most vaginal yeast infections. Your vagina naturally contains a balanced mix of yeast, including candida, and bacteria. Certain bacteria (lactobacillus) act to prevent an overgrowth of yeast. But that balance can be disrupted.

Do yeast infections smell? ›

Yeast infections typically don't cause any noticeable vaginal odors, which sets them apart from other vaginal infections. If there's an odor, it's usually rather mild and yeasty.

What Foods prevent yeast infections? ›

Yogurt with live bacterial cultures. Fermented foods such as kimchi, kefir, kombucha, sauerkraut, and pickles. Supplements containing lactobacillus or acidophilus.

Can stress cause a yeast infection? ›

Women tend to be more likely to get vaginal yeast infections if their bodies are under stress from poor diet, lack of sleep, illness, or when they are pregnant or taking antibiotics. Women with immune-suppressing diseases such as diabetes and HIV infection also are at increased risk.

How do I get rid of yeast in my body naturally? ›

Home remedies for yeast infections
  1. Apple cider vinegar. Apple cider vinegar (ACV) has been found to inhibit the growth of Candida albicans, the strain of fungi that typically causes yeast infections. ...
  2. Boric acid. ...
  3. Coconut oil. ...
  4. Cranberry juice or pills. ...
  5. Garlic. ...
  6. Probiotics. ...
  7. Tea tree oil. ...
  8. Vitamin C.

How often should you shower with a yeast infection? ›

In addition to potentially causing some unpleasant odors down there (though, let me remind you, it's normal for vaginas to smell like vaginas), it can also lead to yeast infections or bacterial vaginosis. So yeah. You're going to want to wash those lady bits once a day.

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